Rybone® is a product developed as a zero carrier solution to support the option for hybridization of graft material (allograft with autologous reconstitution) to benefit from the body's own growth factors. Rybone® provides an optimal micro-environment for mesenchymal stem cell proliferation and protein synthesis. Resorption capabilities allow for Rybone® to be replaced by the patient's own living cells.
The fibrous matrix provides an excellent osteoconductive scaffold with increased osteoinductive potential when compared to putty of any kind; partially attributed to its larger surface area. The inherent biochemical properties of Rybone® collectively result in a superior graft for osseointegration.
A zero carrier solution ensures that product efficacy and safety is greatly enhanced. Rybone® consists of 100% Demineralized Cortical Bone utilizing proprietary processes to create a malleable fibrous structure when hydrated with any bioactive agent. It is engineered with autologous carrier reconstitution in mind.
Experience better aborption performance with (up to) a 1:1 ratio for biologic reconstitution. The superior handling capabilities of Rybone® are evident once reconstituted.
When reconstituted with a bioactive material, Rybone® provides an optimal micro-environment for mesechymal stem cell proliferation in a moldable fibrous product that sticks to the bony void as intended and can effectively withstand irrigation.
It does what you want it to do. Rybone® is intended for the treatment of musculoskeletal defects and can be mixed with autologous Plasma, BMA or Stem Cell prior to use at the physician’s discretion.
The resulting substance is a moldable fibrous product that sticks to the bony void as intended and can effectively withstand irrigation.
Orbbo Biotechnology is an innovator in the field of biotechnology by designing products for Spine Surgery, Maxillofacial Surgery, Orthopedic Surgery, Podiatry, Hand, and Cranial Surgery.
Rybone® fiber allograft may be used in situations where an autograft is appropriate, such as in spinal fusion procedures. It is intended for the treatment of musculoskeletal defects and may be gently packed into intended devices, bony voids or gaps of the skeletal system. These defects may be surgically created osseous defects or osseous defects created from traumatic injury to the bone.
Using a single donor system; the efficacy and safety is greatly enhanced.
Orbbo Biotechnology only accepts donors from federally designated Organ Procurement Organizations (OPOs) or qualified tissue recovery partners. As these organizations are focused primarily on organ donation and tissue recovery.
Each partner is routinely audited to guarantee their recovery practices meet current FDA regulations, AATB standards and Orbbo’s own stringent guidelines.
Prior to release for transplantation, each donor is subjected to a thorough eligibility evaluation including review of the donors medical and social history, hospital records, infectious disease screening, autopsy report (if performed), and physical assessment. Testing* includes, but is not limited to, the following:
Rybone® can be stored at ambient temperature (15°C to 30°C) until expiration date shown on label.
Demineralized bone matrix: basic science and clinical applications. - Pacaccio DJ, Stern SF.1
The clinical use of allografts, demineralized bone matrices, synthetic bone graft substitutes and osteoinductive growth factors: a survey study. - Bostrom MP, Seigerman DA.2
Quantification of various growth factors in different demineralized bone matrix preparations. - Wildemann B, Kadow-Romacker A, Haas NP, Schmidmaier G.3
Effect of platelet-rich plasma combined with demineralised bone matrix on bone healing in rabbit ulnar defects. - Galanis V, Fiska A, Kapetanakis S, Kazakos K, Demetriou T.4
Wildermann B, Kadow-Romacker A, Haas NP, Schmidmaier G. Quantification of various growth factors in different demineralized bone matrix preparations. 2007. J Biomed Mater Res A 81(2):437-442.5
Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells - Rinaldo Florencio-Silva, Gisela Rodrigues da Silva Sasso, Estela Sasso-Cerri, Manuel Jesus Simões, and Paulo Sérgio Cerri.6
Normal Bone Anatomy and Physiology - Bart Clarke.7
All required communicable disease tests are negative/nonreactive. Communicable disease testing was performed by a laboratory registered with the FDA to perform donor testing and certified to perform such testing on human specimens in accordance with Clinical Laboratory Improvement Amendments of 1988 (CLIA) and 42 CFR part 493, or that has met equivalent requirements as determined by the Centers for Medicare and Medicaid Services (CMS). Names and addresses of testing laboratories, and a listing of the documents reviewed as part of the relevant medical records are kept